PHF11 promotes DSB resection, ATR signaling, and HR
نویسندگان
چکیده
منابع مشابه
PHF11 promotes DSB resection, ATR signaling, and HR.
Resection of double-strand breaks (DSBs) plays a critical role in their detection and appropriate repair. The 3' ssDNA protrusion formed through resection activates the ATR-dependent DNA damage response (DDR) and is required for DSB repair by homologous recombination (HR). Here we report that PHF11 (plant homeodomain finger 11) encodes a previously unknown DDR factor involved in 5' end resectio...
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The maintenance of genomic integrity is crucial for the survival of all organisms. In humans, compromised genomic integrity contributes to genetic disorders, aging and cancers. The task of safeguarding the genome is accomplished by the concerted action of a number of cellular processes, including DNA replication, DNA repair, senescence and apoptosis. Many, if not all, of these processes are reg...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2017
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.291807.116